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        NITRALZ? - for the production of various API’s
        NITRALZ? - special solvents for individual requirements
        NITRALZ? - for HPPs & Phthalocyanine Pigments
        NITRALZ? - for the production of various APIs

        Nitriles

        AlzChem - we stand for tradition and innovation

        Located in the south of Germany, AlzChem stands for tradition and innovation: Based on more than 50 years of nitriles experience we have developed and launched several new products using our technology in recent years.

        We offer reliability, quality, flexibility and innovation: State-of-the-art process controls, short production changeover, German precision, proprietary catalysts and a safe supply chain.

        We produce "green": Our gas-phase technology stands for low emissions and reduced waste. Our on-site incinerator converts off-gas to water and carbon dioxide, and in the case of chlorinated benzonitriles to hydrochloric acid which is used in other processes on site.

        Martina Spitzer

        Martina Spitzer

        T +49 8621 86-2727

        martina.spitzer@alzchem.com

        Downloads: 

        NITRALZ? One Source – INNOVATIVE SOLUTIONS

        High quality nitriles via gas phase technology MADE IN GERMANY:

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        Some nitriles are used in different industries as intermediates or solvents.

        Their application varies from UV-absorption to liquid crystals for displays. Converted to Benzylamine, they act as cross linker for rubbers.

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        Please find a few examples of our nitriles used as intermediates for industrial use:

        NITRALZ?

        CAS No.

        application area examples
        Benzonitrile 100-47-0 benzylamine production
        4-Bromobenzonitrile 623-00-7 production of amides
        2-Chlorobenzonitrile 873-32-5 polymerization catalysts

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        NITRALZ? One Source – INNOVATIVE SOLUTIONS

        Our NITRALZ? products are used as intermediates for the API (active pharmaceutical ingredient) production.

        AlzChem is the independent and reliable Western source for many nitriles / gas phase reactions.

        By special distillation we achieve high quality and purity of our nitriles. Furthermore we are proud of our in-house catalyst development. By applying our extensive catalyst Know-How and innovation thoughts we have branched out into additional groups of molecules, like ketones (e.g. 3-Acetylpyridine).

        To meet your needs our R&D works closely with your team to develop advanced chemical solutions.
        Thus the production from gram scale to ton scale is no problem for us.

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        High quality nitriles via gas phase technology MADE IN GERMANY:

        We offer a broad product portfolio for the production of APIs.

        AlzChem features e.g. 2-Chlorobenzonitrile (CAS No. 1867-66-9) available from stock in three different qualities:

        • Standard Quality – ???????? as organic building block for industrial use.
        • Extra Pure Quality – ????? mainly used for the production of Ketamine hydrochloride.
        • Super Quality – ????????????? with the highest purity of min. 99,5%, an outstanding quality is available for active pharmaceutical ingredients.

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        Furthermore our NITRALZ? 4-Aminobenzonitrile serves as essential intermediate for APIs like Dabigatran or Frovatriptan.

        Another product we would like to highlight is our 3-Acetylpyridine, which is used for the production of the API Imatinib.

        Please find here a few examples of our nitriles mainly used as intermediates for pharmaceuticals for human and veterinary use:

        Human medicine application:

        NITRALZ?

        CAS No.

        application area examples

        end product examples

        4-Aminobenzonitrile

        873-74-5

        anti-migrane

        anti-atherosclerotic

        anticoagulant

        treatment of HIV

        anti-cancer

        anti-asthmatic

        Dabigatran

        Frovatriptan

        Goxalapladib

        Rilpivirine

        2-Bromobenzonitrile

        2042-37-7

        anti-hypertensive

        anti-epileptic

        Irbesartan

        Perampanel

        4-Bromobenzonitrile

        623-00-7

        analgesic
        ocular anti-inflammatory

        Bromfenac

        2-Chlorobenzonitrile

        873-32-5

        anti-hypertensive

        analgesic

        hypnotic

        anesthetic

        Sartanes

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        Ketamine? Hydrochloride

        4-Chlorobenzonitrile

        623-03-0

        anti-allergic

        aromatase inhibitor

        Lodoxamide Tromethamine

        2,3-Dichlorobenzonitrile

        6574-97-6 anti-epileptic Lamotrigine

        2,4-Dichlorobenzonitrile

        6574-98-7

        treatment of HIV

        Dolutegravir

        Pivalonitrile

        630-18-2

        bronchodilator

        Pirbuterol

        4-Tolunitrile

        104-85-8

        anti-histaminic

        hemostatic

        anti-ulcerative

        anti-neoplastic

        Letrozole

        3-Acetylpyridine 350-03-8 anti-leukemia drug Imatinib

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        Veterinary medicine application:

        NITRALZ?

        CAS No.

        application area examples

        end product examples

        Benzonitrile

        100-47-0

        antibacterial

        Florfenicol, Robenacoxib

        n-Butyronitrile

        109-74-0

        anticoccidial

        Amprolium

        4-Chlorobenzonitrile

        623-03-0

        contraceptive

        Lotrifen

        3-Acetylpyridine

        350-03-8

        tyrosine-kinase inhibitor treatment of mast cell tumors

        Masitinib

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        Special solvents:

        NITRALZ?

        CAS No.

        n-Butyronitrile

        109-74-0

        Pivalonitrile

        630-18-2

        4-Heptanone

        123-19-3

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        Did you know that …

        Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal indications with more than 20 additional nitrile-containing leads in clinical development.
        The nitrile group is quite robust and, in most cases, is not readily metabolized but passes through the body unchanged. The types of pharmaceuticals containing nitriles are diverse, from vildagliptin, an antidiabetic drug, to anastrozole, which is the gold standard in treating breast cancer. In many instances the nitrile mimics functionality present in substrates for enzymes, whereas in other cases the nitrile increases water solubility or decreases susceptibility to oxidative metabolism in the liver. The nitrile functional group is found in several drugs. (Fleming et al. 2010: 7902)

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        Fleming, Fraser F.; Lao, Lihua; Ravikumar, P.C; Funk, Lee and Shook, Brian C. (2010): Nitrile-Containing Pharmaceuticals. Efficacious Roles of the Nitrile Pharmacophor, in: Journal of Medicinal Chemistry. 53 (22), pp 7902-7917.

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        NITRALZ? One Source – INNOVATIVE SOLUTIONS

        Nitriles serve as special solvents for individual requirements. These high quality solvents are used in agriculture, pharmaceutical and industrial application. Aliphatic nitriles and the aromatic derivative, Benzonitrile, are attracting increasing attention as specialty solvents in organic synthesis.

        Their dipolar, aprotic properties, their solvent characteristics, such as the dissolution capacity of polar chemicals and the liquid range allow the user to choose the ideal solvent for every application. What′s more, they are stable and inert in many chemical conversions and can be used at a wide temperature range.

        High quality nitriles via gas phase technology MADE IN GERMANY:

        SOLVENT CAS No. MOLECULAR WEIGHT (g/Mol) MELTING POINT?? (°C) BOILING PONT?? (°C) FLASH POINT (°C) DENSITY (g/ml) SOLUBILITY IN WATER (g/100g) DIELECTRIC CONSTANT APPLICATIONS
        Benzonitrile 100-47-0 103.1 -13 191 67 1.01 0.40 26.0 The most popular and most versatile aromatic nitrile solvent; more stable than acetonitrile (no labile α-H atom!)
        Butyronitrile 109-74-0 69.11 -112 117 18 0.79 3.35 20.3 Standard solvent with a broad temperature range
        Decanonitrile 1975-78-6 153.3 -18 241-244 102 0.81 Traces 10.6 High temperature applications, surface active compound
        Isobutyronitrile 78-82-0 69.11 -72 104 8 0.77 3.70 20.4 The alternative to butyronitrile
        Pivalonitrile 630-18-2 83.13 15-16 104-106 4 0.76 4.7 21.1 Ideal solvent for organic and organometallic transformations due to a bulky tert-butyl group
        Valeronitrile 110-59-8 83.13 -96 141 34 0.80 1.30 17.4 Medium polar solvent with a broad temperature range; pharmaceutical applications, e.g. WO2006010545A1

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        Polarity and liquid range of NITRALZ? solvents:

        NITRALZ? One Source – INNOVATIVE SOLUTIONS

        Crops are exposed to different kinds of threats worldwide. The agro industry provides various solutions to protect them.

        For the production of such agricultural products, like special fungicides, insecticides and herbicides nitriles are used.

        In many innovations of agricultural products, our nitriles serve as an important component.

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        NITRALZ? stands for high quality of aromatic and aliphatic nitriles MADE IN GERMANY.

        Our customers benefit from our long experience and our competence in high temperature reactions. We are also proud of our in-house catalyst development.

        We guarantee high quality, efficient technologies, innovative processes and a high standard to service our partners.

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        We offer you a broad product portfolio of various intermediates for agrochemicals.

        Here a few examples of our commercial nitriles mainly used in the agrochemical sector:

        NITRALZ? CAS No. application area examples end product examples specification
        Benzonitrile 100-47-0 herbicide, solvent Fenclorim ≥ 99,6%
        n-Butyronitrile 109-74-0 solvent ? ≥ 99,5%
        Caprinonitrile 1975-78-6 fungicide, solvent Ametoctradin ≥ 98,0%
        2-Chlorbenzonitril2-Chlorbenzonitril2-Chlorbenzonitril2-Chlorobenzonitrile 873-32-5 biocide BenzisothiazolinoneBenzisothiazolinone ≥ 99,00%
        4-Chlorobenzonitrile 623-03-0 acaricide, insecticide

        Tolfenpyrad

        ≥ 99,5%
        2,3-Dichlorobenzonitrile 6574-97-6 pesticide ? ≥ 99,5%
        2,6-Dichlorobenzonitrile 1194-65-6 herbicide, insecticide Diclobenil, Dimilin, Pyrithiobac ≥ 99,0%
        3,4-Dichlorobenzonitrile 6574-99-8 herbicide Cyhalofop

        ≥ 99,5%

        Pivalonitrile 630-18-2 solvent ? ≥ 99,0%

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        Did you know that 2,3-Dichlorobenzonitrile is new in the AlzChem portfolio since 2015?

        AlzChem has extended the product range with another aromatic nitrile. 2,3-Dichlorobenzonitrile (CAS No. 6574-97-69) is new in the AlzChem portfolio. Its main application is in the life science segment.

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        NITRALZ? One Source – INNOVATIVE SOLUTIONS

        High quality nitriles via gas phase technology MADE IN GERMANY:

        We offer you a broad product portfolio for the production of your Diketopyrrolopyrrol-Pigments (DPP Pigments).

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        Our NITRALZ? products are used as intermediates for example for the following High Performance Pigments (HPP):

        NITRALZ?

        CAS No. used for the production of specification
        Benzonitrile 100-47-0 Pigment Red 255 (PR 255) ≥ 99,6%
        4-Bromobenzonitrile? 623-00-7 orange-red ≥ 99,0%
        3-Chlorobenzonitrile 766-84-7 orange-red ≥ 99,0%
        4-Chlorobenzonitrile 623-03-0 Pigment Red 254 (PR 254) ≥ 99,5%
        o-Phthalodinitrile 91-15-6 Pigment Yellow 139 (PY 139) ≥ 99,5%
        o-Phthalodinitrileo-Phthalodinitrile 91-15-6 Pigment Yellow 185 (PY 185)

        ≥ 99,5%

        4-tert.-Butylbenzonitrile 4210-32-6 Pigment Orange 73 (PO 73) ≥ 98,0%
        4-Tolunitrile 104-85-8 Pigment Red 272 (PR 272) ≥ 98,5%

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        DPP-Pigments are very resistant against light, weather, solvents, heat and chemicals and so they are suitable for quality formulations.

        ?

        Our o-Phthalodinitrile (OPN) can also be used for the production of Phthalocyanines:

        NITRALZ?

        CAS No. used for the production of specification
        o-Phthalodinitrile 91-15-6 Phthalocyanine Blue 15 (PB 15) ≥ 99,5%
        o-Phthalodinitrile 91-15-6 Phthalocyanine Green 7 (PG 7) ≥ 99,5%
        o-Phthalodinitrile 91-15-6 Phthalocyanine Green?36 (PG 36) ≥ 99,5%

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        Our OPN has a very high purity and is characterized by low impurities and metal content.

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        Using OPN instead of the route using phthalic acid anhydride brings the following advantages in producing phthalocyanine pigments:

        • More brighter and brilliant pigments.
        • Only one reaction step is required.
        • Direct synthesis with very little formation of by-products and waste water.
          (The structure of the Phthalocyanine is already preformed in the o-Phthalodinitrile)
        • Economic advantages (– because via the PSA route there is only a yield of around 80% and so many by-products have to be disposed of).

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        We can offer our nitriles in different packaging like cardboard boxes, steel drums and iso-containers.

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        Did you know that …

        Some of the aromatic nitriles are used to manufacture organic pigments, diketopyrrolopyrroles (DPPs). They are obtained through the condensation of two molecules of nitrile with dimethyl succinate. Depending on the substitution pattern they create yellow, orange, orange and red color pigments. The pigments are used in automotive paints, to dye plastics, in emulsion paints and others. The best-known is certainly PR 254, Irgazine? Red.

        PR 254

        This pigment provided for the first time a relatively non-toxic and light-fast alternative to Zinnober Red and to the later Cadmium Red. Its inclusion in an automotive paint for a very special car has given this red pigment its nickname – Ferrari Red.

        News

        As a supplier of raw materials for the pharmaceutical industry, AlzChem is now also helping to produce “corona tests”: intermediate products from AlzChem are used in both tests that detect SARS-CoV-2 and the tests used to detect antibodies.   For many years AlzChem has been reliably supplying various pharmaceutical companies with the two intermediate products guanidine hydrochloride and guanidine thiocyanate. Both are now also used to manufacture the corona tests that are currently...
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        Many years of extensive experience in complex organic chemistry - including moisture-free and oxygen-free organometallic reactions as well as large-scale Grignard reactions in diethyl ether - are among the traditional core competencies of AlzChem. Thanks to the extensive knowledge of the experts on the reactivity of cyanamide, the company was able to establish numerous intermediates for medications based on NCN chemistry on a commercial scale in its multipurpose facilities, including cancer...
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        From the group of organosilicon compounds, triethylsilane is used as a reducing agent and for hydrosilylation. The high product purity of triethylsilane is crucial for the pharmaceutical industry, especially for new developments of highly effective antivirals. An antiviral drug inhibits the multiplication of viruses and therefore is used as a drug in the treatment of infectious diseases caused by viruses. REACH registered, triethylsilane has been produced in large volumes for over 10...
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        We are proud about our investment in a new additional distillation column in the amount of € 7.2 million, which was successfully started on schedule in early July 2019. Thus we can serve our customers including our products 2,6-Dichlorobenzonitrile and p-Chlorobenzonitrile at a reliable high level of quality. Furthermore, our entire team responded excellently to the changing demand on the world market and carried out a corresponding optimization of the product mix. This means that we...
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        Events

        2020-11-11 to 2020-11-12
        ?Reliability is our trademark: Chemspec Europe is traditionally a fixed date in AlzChem’s calendar being again represented with its own booth. This time the show is from 11th to 12th November, in Cologne. On top of our standard portfolio...
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        2020-11-10 to 2020-11-12
        ?DYHARD? will be present at COMPOSITES EUROPE 2020, the 15th European Trade Fair & Forum for Composites, Technology and Applications again. Our special focus: a fluid system for filament winding of composite pressure vessels. We are...
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