<bdo id="et704"></bdo>
      
      
        Guanidine Salts for biotechnological, diagnostic and pharmaceutical applications

        Guanidine Salts

        High-quality Guanidine Salts for biotechnological, diagnostic and pharmaceutical applications

        As a major world producer of the starting material, dicyandiamide, AlzChem can offer guanidine salts with a wide range of applications from the automotive to the biopharmaceutical industry:

        Guanidine Nitrate is a key ingredient for the manufacture of propellants for airbags. It is also used in fireworks and is the starting material for captive production of Nitro Guanidine.

        Technical Guanidine Hydrochloride, Guanidine Phosphate and Guanidine Sulfamate have applications as flame retardants for textiles and wood, as well as for electroplating.

        Ultrapure Guanidine Carbonate has application in the cosmetics field.

        Due to their chaotropic character both ultrapure Guanidine Hydrochloride and Guanidine Thiocyanate are used as protein denaturants in the development and production of biopharmaceuticals and their generic versions called biosimilars. In addition, they are useful for the extraction of DNA and RNA in molecular diagnostics.

        Verena L?ber

        Verena L?ber

        T +49 8621 86 2622
        verena.loeber@alzchem.com

        ?

        Worldwide, AlzChem offers the highest assurance of supply, since we are the only company backward integrated to the essential raw material, calcium carbide.

        By the precise selection of raw materials and strict quality control throughout our production chain, we can assure and maintain the highest product quality.

        All of our production sites are ISO-certified and provide back-up capacities to assure?security of supply. Products for the pharmaceutical industry are manufactured utilizing the GMP philosophy.

        ?

        Custom-made buffer solutions

        As service for our pharmaceutical customers we develop and produce custom-made buffer solutions of Guanidine Hydrochloride and Guanidine Thiocyanate for biotechnological applications.

        ?

        At a glance:

        • Assured and sustainable high quality
        • Production in dedicated plants
        • Customized packaging from laboratory to commercial sizes
        • Custom-made solutions based on Guanidine Hydrochloride and Guanidine Thiocyanate

        Guanidine Hydrochloride (technical grade)

        • Wood coating and textile treatment
        • Production of biocides
        • Electroplating
        • Synthesis of heterocycles especially for pharmaceutical and crop protection products

        ?

        Ultrapure Guanidine Hydrochloride (biotechnological grade) for denaturation and renaturation of proteins

        Downstream processing in biopharmaceutical manufacturing

        • Isolation and extraction of monoclonal antibodies or recombinant proteins (dissolving of inclusion bodies)
        • Cleaning of industrial separation columns
        ?

        Studies

        • Unfolding and refolding of natural and recombinant proteins
        • Examination of physical-chemical properties of proteins

        ?

        Molecular diagnostics

        • Extraction buffers for the isolation of DNA and RNA from biological specimens
        • Virus diagnostics (test kits for viral RNA/DNA)
        • Sample preparation for PCR-based diagnostics
        • Forensic testing of DNA
        ?

        Product overview – Guanidine Hydrochloride

        Product???????????????????????????????????????????????????? Purity????

        ??????????????????????????????????????????????????????????????????????

        Packaging?????????????????????????????????????????????????????????????????????????????????????????????????????????????????

        Guanidine Hydrochloride for biotechnological, diagnostic and pharmaceutical applications:
        AA-Grade > 99.7%

        UV-Abs.
        (6 M < 0.1 bei 230 nm)

        1 kg PE bottle

        MBG-Grade
        (molecular biological grade),
        ultrapure

        > 99.7% UV-Abs.
        (6 M < 0.03 bei 260 nm)

        10 kg or 20 kg PE drum with special inliner and drying agent

        BPG-Grade
        (biopharmaceutical grade),
        ultrapure
        > 99.5% UV-Abs.
        (6 M < 0.05?at 260 nm)
        10 kg or 20 kg PE drum with special inliner and drying agent
        LC-Grade, 55 % solution > 99.0% UV-Abs.
        (6.7 M < 0.30 bei 260 nm)
        30 L PE canister, 200 L PE drum, 1000 L IBC
        LC6-Grade, 50 % solution > 99.0% UV-Abs.
        (6 M < 0.1 at 260 nm)
        200 L PE drum, 1000 L IBC container, 200 L sterile, manifold packaging
        LC7-Grade, 60 % solution > 99.0% UV-Abs.
        (7.4 M < 0.35?at 260 nm)
        30 L PE canister, 200 L PE drum, 1000 L IBC
        Guanidine Hydrochloride for or technical application:
        with anticaking agent > 98.0%

        Containing 0.2 – 0.4 % anticaking agent

        25 kg PP bag with PE inliner

        without anticaking agent > 98.0% ?

        25 kg PP bag with PE inliner

        ?

        Ultrapure Guanidine Thiocyanate for denaturation of proteins and isolation of DNA and RNA:

        Molecular diagnostics

        • Extraction buffers for the isolation of DNA and RNA from biological specimens
        • Virus diagnostics (test kits for viral RNA/DNA)
        • Sample preparation for PCR-based diagnostics
        • Forensic testing of DNA

        ?

        Product overview – Guanidine Thiocyanate

        Product???? Purity???????? ????????????????????????????????????????????????? Packaging??????????????????????????????????????????????????? ?
        Guanidine Thiocyanate ?
        ultrapure > 99.0%

        UV-Abs.
        (3 M < 0.4 at 280 nm)

        20 kg PE drum with PE inliner ?
        pure > 98.5% UV-Abs.
        (3 M < 0.5 at 280 nm)
        20 kg PE drum with PE inliner ?
        pure, wet > 98.0% Water content max. 2.0 % 20 kg or 40 kg PE drum with PE inliner ?

        News

        As a supplier of raw materials for the pharmaceutical industry, AlzChem is now also helping to produce “corona tests”: intermediate products from AlzChem are used in both tests that detect SARS-CoV-2 and the tests used to detect antibodies.   For many years AlzChem has been reliably supplying various pharmaceutical companies with the two intermediate products guanidine hydrochloride and guanidine thiocyanate. Both are now also used to manufacture the corona tests that are currently...
        read more
        Many years of extensive experience in complex organic chemistry - including moisture-free and oxygen-free organometallic reactions as well as large-scale Grignard reactions in diethyl ether - are among the traditional core competencies of AlzChem. Thanks to the extensive knowledge of the experts on the reactivity of cyanamide, the company was able to establish numerous intermediates for medications based on NCN chemistry on a commercial scale in its multipurpose facilities, including cancer...
        read more
        From the group of organosilicon compounds, triethylsilane is used as a reducing agent and for hydrosilylation. The high product purity of triethylsilane is crucial for the pharmaceutical industry, especially for new developments of highly effective antivirals. An antiviral drug inhibits the multiplication of viruses and therefore is used as a drug in the treatment of infectious diseases caused by viruses. REACH registered, triethylsilane has been produced in large volumes for over 10...
        read more
        We are proud about our investment in a new additional distillation column in the amount of € 7.2 million, which was successfully started on schedule in early July 2019. Thus we can serve our customers including our products 2,6-Dichlorobenzonitrile and p-Chlorobenzonitrile at a reliable high level of quality. Furthermore, our entire team responded excellently to the changing demand on the world market and carried out a corresponding optimization of the product mix. This means that we...
        read more

        Events

        2020-11-11 to 2020-11-12
        ?Reliability is our trademark: Chemspec Europe is traditionally a fixed date in AlzChem’s calendar being again represented with its own booth. This time the show is from 11th to 12th November, in Cologne. On top of our standard portfolio...
        read more
        2020-11-10 to 2020-11-12
        ?DYHARD? will be present at COMPOSITES EUROPE 2020, the 15th European Trade Fair & Forum for Composites, Technology and Applications again. Our special focus: a fluid system for filament winding of composite pressure vessels. We are...
        read more
        能上下分的棋牌游戏